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Such high GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77
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This high metabolic demand renders ocular tissues particularly vulnerable to metabolic dysregulation, which can precipitate an energy crisis leading to retinopathy, AMD, and other pathologies
Diabetes Obes Metab 15(1):1527 Sharma D et al (2018) Recent updates on GLP-1 agonists: Current advancements & challenges
Under "Glucagon signaling in the failing heart" (p
