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Endocrinologist John Wilding noted: "It was exciting, because all of a sudden we were in a league where we knew it would be much more impactful in terms of the effects on health." A year-long study (2018) of nearly 900 people with obesity found that between one-third and half taking semaglutide lost at least 15% of body weight, with at least three-quarters losing more than 5%

Dietary intake is the strongest physiological factor that stimulates PYY (1-36) secretion