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The above portrayal of the gutbone axis in anti-osteoporosis, on the one hand, stimulates a broader management mindset for active health of the skeleton, and, on the other hand, highlights the key involvement of intestinal factors in systemic pathogenesis, which is expected to provide theoretical basis for disease intervention strategies that target the gut and the clinical implementation of micro-ecological preparations ( Figure 5 )

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For each set of parameters, the model was tested for two features: (i) exact adaptation in response to a single step (1.15 mM) of the stimulus