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doi: 10.1038/s41392-021-00507-5 160 EliasEELyonsBMuruveDA

It primarily works by inhibiting Nicotinamide N-methyltransferase (NNMT), an enzyme linked to fat cell metabolism and energy expenditure

PMID: 74

Proteases are used to decrease mix time and increase elasticity but are not reducing agents

With meals: take with carbohydrates to maximize cellular uptake (insulin helps absorption)

Conversely, if a patient presents with pernicious anemia or severe neurological signssuch as intense tingling in the hands, memory loss, or muscle weaknessthe dosage remains the same (usually 1,000 mcg), but the frequency increases significantly