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What do we monitor over time

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The GLP1R weight loss finding from the main study did not replicate in the UK Biobank, though the authors note that the UK Biobank group was too small to reliably detect the effect

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Overall, our data are consistent with the possibility that persistent activation of DAF-16 starting on day 1 of adulthood could be essential for lifespan extension

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In September 2024, after patient enrollment was complete, the company announced the trial failed to meet its primary cognitive efficacy endpoints

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