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CYP2E1 and ALDH enzymatic activity CYP2E1 activity was assessed by measuring the rate of oxidation of p -nitrophenol (PNP) to p -nitrocatechol as described 54
Because AOD9604 does not stimulate IGF-1 production and lacks strong GH receptor agonism, it may present a safer alternative for long-term OA treatment [1]
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The mechanism is not well established it may relate to individual sensitivity, dehydration coinciding with supplement use, or other unrelated factors
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