Our group reported that enhanced beta-cell GLP-1R signaling activates alpha-cell PC1/3 expression and GLP-1 production, which is associated with improved glucose tolerance and GSIS following VSG in mice ( Figure 4 )
Mechanistically, METTL3 mediates the m6A modification of these SSPrelated genes, while IGF2BP3, functioning as an m6Aspecific reader, inhibits the degradation of their mRNAs
But weighing the two, seeing thousands of patients over this period of time, they really start to embrace the disease concept because for them it puts together oh, now I understand why it is so difficult for me to reduce my calories long term and keep my weight off
Kojima M, Hosoda H, Date Y, et al
Not every study shows the same magnitude of benefit
GLP-1 drugs like semaglutide help lower blood sugar and cut down heart risks in patients more likely to have heart problems