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One reason for the large difference between the headline Reta number (12 mg, -26.1% pbo-adjusted) and the ITT number (-21.1%) is probably a high overall patient drop-out rate

The time-to-onset interval was subsequently computed as the temporal difference between EVENT_DT (the recorded date of adverse event manifestation) and START_DT (the documented date of therapeutic intervention initiation)

S.ThiruchelvamK

Exposures Prescriptions for semaglutide vs nonGLP-1 RA medications to manage either T2D or weight

Increased Burden : Mandatory enrollment in health programs and regular check-ins create additional hurdles for patients

Your starting point is that elevated 1.6x reservoir, not a single-dose level