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SARS-Cov-2 protease 3CL maintains the same Gln189 site (105) of SARS-Cov 3CLpro, which previously was identified as the binding site for the hydroxyl groups of quercetin and its derivates (102)
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Some peptides create biochemical conditions that make other peptides more effective
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50 Similarly, upregulation of thymidylate synthase (TYMS), a target of 5-fluorouracil (5-FU), contributes to resistance in colorectal cancer by augmenting DNA repair pathways
Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition
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