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doi: 10.1123/japa.2018-0351
Notably, while total FOXO4 protein levels remained consistent between young and elderly men, a striking age-dependent shift in its subcellular localization was observed: FOXO4 predominantly resided in the cytoplasm in young Leydig cells but translocated to the nucleus in aged cells
M., Giorcelli, G., D'Iddio, S., Valentini, G., Bagiella, E., Procopio, A., di Donato, S., Ashbrook, D., and Corsi, M
When co-cultured with THP-1 macrophages, OCSLCs increase the expression of M2 markers such as CD163, while boosting the secretion of anti-inflammatory cytokines like IL-10 and pro-tumor factors such as VEGF and MMP-9, which are characteristic of M2 macrophages
