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The consequence that actually shows up on a bench is this: in a serum-containing medium, the free fraction of added IGF-1 LR3 is much higher than the free fraction of an equal mass of native IGF-1, and it is far less buffered, because the binding-protein reservoir that would normally absorb an excess and release it slowly is largely not engaging with this molecule
doi: 10.1038/s41575-019-0158-2 58 WangDHanSLvGHuYZhuoWZengZet al
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Exenatide works more quickly but with similar benefits
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