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Mutations in LRRK2 impair its function and disrupt the formation of aggressive aggregates (aggresomes) that normally facilitate the autophagic clearance of protein aggregates ( In genetic inherited forms of PD such as those linked to GBA1 gene mutations, autophagy seems to play a central role in the pathogenesis of disease

These same molecules were also subsequently approved for weight lossliraglutide in 2014, and semaglutide, as Wegovy, in 2021

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Patients should seek immediate medical attention if experiencing severe, persistent abdominal pain radiating to the back

Patients are generally encouraged to follow provider recommendations regarding alcohol use, hydration, nutrition, exercise recovery, medications, and overall wellness habits while participating in a peptide therapy program