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Ju YS, Zangrilli MA, Finn MB, Fagan AM, Holtzman DM
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High-throughput screening suggests glutathione synthetase as an anti-tumor target of polydatin using human proteome chip
Nutrient Deficiencies (Building Blocks Missing) Glutathione synthesis requires specific nutrients: Cysteine : From dietary protein (whey, eggs, poultry)-rate-limiting Glycine : Often deficient in modern diets (need 10-15g/day, most get 3-5g) Selenium : Cofactor for glutathione peroxidase (GPx) , the enzyme that recycles GSSG back to GSH B vitamins (B6, B9, B12): Required for methylation and sulfur metabolism Vitamin C : Recycles oxidized glutathione Deficiency in any of these impairs glutathione production or recycling [5]
Sultan evaluates therapies thoughtfully and incorporates those that align with her philosophy of personalized, patient centered care
However, the main concern with oral delivery is bioavailability, or how much of the peptide is absorbed into the bloodstream after digestion
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