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Increase of organic acids and coenzymes In the present study, we identified other classes of compounds that underwent significant changes, such as purines and pyrimidines, coenzymes, organic acids, anti-oxidants, and sugar metabolites (in plasma, not RBCs), revealing hitherto unrecognized aspects of fasting

In both experimental models and human diabetic subjects, there is an initial metabolic phase that is responsive to metabolic corrections [90, 91]

That is indirect and individual, works over weeks, and only if a provider decides it is appropriate

The short answer: there is promising but limited evidence

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Understanding why the evidence for DSIP is weak, and being able to say so plainly, is itself a clinical skill