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It is important to note that including patients with a known history of depression and/or anxiety in such studies could bias the results, as these patients are more prone to experience a new episode, which could be wrongfully attributed to GLP-1 RAs drugs
Ozempic and metformin are different in several ways
However, this approach is not routine first-line treatment in UK practice, is considered off-label, and requires good patient adherence and clinical follow-up
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Psychiatry 27 , 33963409 (2022)
The microarray data were processed with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) and are included in Supplementary Table 1
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