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In contrast, GSH depletion drives M1 polarization, resulting in heightened secretion of pro-inflammatory cytokines, including TNF-, IL-6, and IL-1 ( Overall, GSH helps limit unwanted immune attacks in the brain

Activated microglia release even more neurotoxic mediators, perpetuating a state of chronic neuroinflammation

Glutamine fuels proliferation but not migration of endothelial cells

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It is possible to increase glutathione levels through oral or intravenous (IV) supplementation

Glutathione Glutathione is a tripeptide antioxidant composed of glutamate, cysteine, and glycine that serves as the bodys master antioxidant and plays a critical role in cellular detoxification and skin health [65, 66]