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Common gastrointestinal side effects include nausea, vomiting, diarrhea, constipation, and abdominal pain

Gastrointestinal side effects, including changes in bowel frequency, are most pronounced during the initial weeks of treatment and following dose increases

Step-up dosage: Increase to 4 mg once daily for the next 30 days, then increase again if needed

Keep the pen cap attached to protect the medicine from light

The latter workers also showed that diethyl maleate pretreatment of rats inhibited the glutathione conjugation of subsequently-adminis tered bromsulphthalein

These applications represent off-label use, and the evidence is primarily from small trials and observational studies