Blood levels peak around age 20 at approximately 200 ng/mL and decline to roughly 80 ng/mL by age 60, correlating with diminished skin elasticity and regenerative capacity
This reciprocal relationship is critical, as disruptions in the gut microbiota are associated with liver diseases (51)
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In addition to membrane transport, lactate also functions as a signaling molecule via its receptor GPR81 (HCAR1)
When gastrointestinal symptoms occur, they often relate to supplement formulation, excipients, or underlying health conditions rather than the vitamin itself