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Supraphysiological testosterone concentrations have been shown to reduce endothelial nitric oxide synthase expression and nitric oxide bioavailability, thereby favouring vasoconstriction and increased arterial stiffness (73)

The Cu ion bound to the GHK tripeptide is integral to its ability to activate copper-dependent enzymes, stimulate collagen synthesis, modulate antioxidant defence systems, and regulate gene expression in research models

The increased GABA level induced by exogenous GABA altered levels of stress response substances such as glutamate, polyamines and anthocyanins in association with improved cold tolerance

These included phosphatidylethanolamine, phosphoserine (PS), phosphatidylcholine, and phosphatidylinositol

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Research demonstrates bidirectional gut-brain communication: peripheral BPC-157 administration increased brain serotonin synthesis, produced antidepressant effects, and prevented brain lesions in intestinal resection models