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128 Additionally, thalidomide inhibits M1 macrophage polarization by targeting the transcription factor IRF5, reduces the release of inflammatory signals, significantly reduces the secretion of the proinflammatory cytokines IL-12 and IFN-, and promotes intestinal mucosal healing
Table 1 shows the final models parameter estimated values and bootstrap, where the 1,000 bootstraps median values are near to the corresponding final models parameter values, showing that the final model was accurate and reliable
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Rai R, Mahapatra S, Bhalla A, et al
For developers, integrating safety and ESHS thinking early in the design process may therefore be as important as achieving a desired biological effect