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Among these elements, ATF3 predominantly regulates the basal and stress-induced expression of ChaC1 through ATF/CRE, while ATF4 primarily regulates stress-induced ChaC1 expression through ATF/CRE and ACM (48)
ShiotaMSugaiNTamuraMYamaguchiRFukushimaNMiyanoTet al
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Important caution: Given the dual role of glutathione in cancer biology, glutathione or NAC supplementation should NOT be taken during active cancer treatment without oncologist approval, as it could theoretically protect tumor cells from therapy [2][5]
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