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Recent studies suggest that GLP-1 also mediates the metabolic effects of metformin, gut microbiota, and bariatric surgery 3,4,5,6
They act on the GLP-1 receptor, which is expressed in the brainespecially in centers that regulate appetiteas well as peripherally, like in the gastrointestinal tract and heart
IUBMB Life 75:811829
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doi: 10.1159/000343971 177 SerafiniG
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