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The three most effective (semaglutide, tirzepatide, retatrutide) are GLP-1 agonists: they mimic a natural gut hormone that tells your brain you are full
Widely used in research settings requiring complex compound combinations
A 500mcg daily protocol under split dosing would look like: 300mcg upon waking (fasted), then 200mcg approximately 30 minutes before dinner or before bed on an empty stomach
Clinical evidence strength: AOD 9604 is weak, having failed six trials
the STEP-1 trial reported approximately 14.9 percent on semaglutide over 68 weeks
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