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MCH neurons project to the nucleus accumbens (Nac), whereas orexin neurons project to the ventral tegmental area (VTA), two brain areas involved in the reward system ( Moreover, it is important to note that besides the control of food intake by acting on the brain ( via endocrine and nervous routes), the main functions exerted by the gut peptides secreted are also linked to gastric emptying and intestinal motility, the regulation of secretion from the pancreas and the gallbladder and the stimulation of insulin secretion, also known as the incretin effect