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free acid) L-threonine glycoamino acid carrying a Galβ1-3GalNAcα disaccharide
Two sequential enzymatic reactions are typically required: removal of the 2-O-sulfate by IDS
Fmoc-L-Asn(GlcNAc(Ac)3-β-D)-OH
72 / MUC1 (UniProt ID P15941) synthetic glycopeptide fragment (Pro126-Gly149
/ IgA1(208-245)-Tn(230) / Immunoglobulin heavy constant alpha 1 (IGHA1)
AG142000: α-D-GalNAc-Butyl-Carboxylic Acid Pack Size:100 mg free acid) L-threonine glycoamino acidC13H23NO8 321. 32 An D N acetylgalactosamine (GalNAc) ligand equipped with a terminal carboxylic acid through a short butyl spacer. The carboxylic acid can be activated to NHS, sulfo NHS, or pentafluorophenyl (PFP) esters and reacted with amine functionalized platforms or lysine residues on proteins and peptides to form stable amide bonds. This compound enables the construction of hepatocyte targeted therapeutics and research tools that exploit the
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