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Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]

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10.1016/j.metabol.2020.154334 162 LiuX.LiuS.ZhangB.LuoD.HuangS.WangF.et al (2021)

If 300 mcg is insufficient, the problem likely requires a different intervention, not more DSIP

Mol Pharmacol 46:909914 Kim SK, Woodcroft KJ, Khodadadeh SS, Novak RF (2004) Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes

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