For the first time, large numbers of patients are achieving sustained, clinically-significant weight loss, often 15 to 20 per cent of body weight in under a year
Standard errors for the I ox /I red values were calculated by propagating the signal-to-noise ratio of the individual spectra using the equation below 68 : where I ox /I red is the calculated error in the I ox /I red ratio, I ox is the noise level of the oxidized spectrum, and I red is the noise level of the reduced spectrum
Oxidative lipidomics is a powerful technique to study lipid oxidation, and other methods to detect lipid peroxidation include the use of C11-BODIPY or Liperfluo probes by fluorescence microscopy (58)
Approved medications should be strongly preferred over investigational research compounds
Red flags requiring immediate evaluation include severe abdominal pain (possible pancreatitis), persistent vomiting leading to dehydration, suicidal thoughts, development of new eating disorder behaviors, syncope, chest pain, hematemesis/melena, severe constipation/obstipation, orthostatic hypotension, or marked electrolyte abnormalities
We used unpaired one-way ANOVA analysis (ANOVA) to assess the significance of differences in mean values between experimental groups, and Tukey's posthoc test was used to adjust multiple comparisons between experimental groups