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Mean weight loss further increased at 36 weeks for those receiving orforglipron to 9.4% with the 12 mg dose, 12.5% with the 24 mg dose, 13.5% with the 36 mg dose and 14.7% with the 45 mg dose compared with 2.3% with placebo

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They measure their dose

The cost of medication is not included in the monthly membership fee

These result in reduced quality of life and higher healthcare costs

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