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Different receptor targets mean different downstream effects

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Compound 6 exhibited only marginal efficacy of 16% and 7% decrease in worm and egg burdens, respectively

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Within the HBP, fructose-6-phosphate is converted into glucosamine-6-phosphate and is subsequently metabolized into uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a crucial metabolite for O- and N- linked protein glycosylation, supporting various EC functions and cardiovascular pathology [70, 71]