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The inverse molecular docking fingerprinting methodology is still in its infancy, and we believe that future studies can expand on the methodology to study different classes of natural and synthetic compounds, and gain valuable insight into the bioactivity trends in the examined chemical space, leading to the repurposing of existing drugs or discovery of novel mechanisms of action

A qualifying reclassification must be to Category 1 of the Bulk Drug Substances List or an equivalent classification that allows interim compounding of the drug

However, when used chronically or at higher doses, that slowed motility can evolve into functional paralysis of the stomach, the hallmark of gastroparesis

Gibson 2017)

It's a cascade

There was no change in the absorption spectrum of the reaction mixture after 30 min