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Dulaglutide is a once-weekly GLP-1RA consisting of the fusion of two identical sequences (the N-terminal portion of the native GLP-1) covalently bound by a peptide linker to the Fc component of a modified human immunoglobulin G4 heavy chain [21]
Notably, nifedipine, an MCP-1 antagonist, has been reported to improve bloodbrain barrier function in SAP rats by downregulating MCP-1 expression
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The ongoing advancements in peptide synthesis and the exploration of bioactive peptides hold promise for innovative therapeutic applications
