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In the elderly population, the overall decrease in magnesium levels occurs due to a decrease in bone mass, which is a major magnesium source
Furthermore, ketamine alters key signaling pathways, such as the CaMKII-ERK1/2-CREB/NF-B axis, leading to reduced synaptic protein expression, synaptic plasticity impairment, and neurodegeneration (Luo et al., 2021)
Ann Intern Med [Internet]
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