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It is a problem that needs addressing
Some people feel better on semaglutide, while others tolerate tirzepatide more easily
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However, native GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) and cleared renally, resulting in a plasma half-life of approximately 23 min [20, 21]
The Lancet, 376 (9738), 2627
That is an important framing for anyone tempted to treat it as a shortcut: even in the animal work that generates the interest, the compound is one input alongside energy balance, not a replacement for it
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