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For PD, the aim is to protect dopaminergic neurons, improve mitochondrial function, reduce -synuclein accumulation and formulate gene therapies

Notably, Compound 74 forms unique hydrogen bonds with Y524, Q726, and H525 and a coordination interaction with Mg, which collectively contribute to its high selectivity and affinity for PDE10A (Figure 20A)

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GLP-1 Agonists Market size was valued at US$ 37,113.2 billion in 2025 and is expected to reach US$ 118,926.1 billion by 2032, growing at a significant CAGR of 18.1% from 2026-2032