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Purging occurs because copper peptides accelerate skin cell turnover

J Invest Dermatol (2015) 135(6):151020

This can happen due to certain health issues or diet

10.1016/j.tig.2013.06.003 40 HarrisJ

415,416,417 GLP-1RAs can exert their local effects by activating vagal dendritic terminals that innervate the gut

A 2022 double-blind, benchmark- and placebo-controlled RCT by Duperray, Sergheraert, and colleagues in the Journal of Cosmetic Dermatology (n=124 Asian women, 12 weeks) found that oral L-cystine plus reduced L-glutathione significantly lightened skin and reduced facial dark spot size at both 6 and 12 weeks versus placebo