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No controlled pediatric safety data exist
For example, genistein inhibits DNMT, promoting the expression of the anti-fibrotic miRNA miR-29, while EGCG (epigallocatechin gallate) inhibits HDAC, thereby upregulating miR-15 expression, which prevents apoptosis (Wang et al., 2021
The resultant effect of the process is decreased oxidative stress, inflammation, and apoptosis, and delayed or prevented aging, thus promoting longevity (see Fig
Patches can be worn during sleep
Practitioners report that most patients are willing to continue if they perceive any benefit