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If the issue persists, its a good idea to talk to your healthcare provider to discuss how to manage Zepbound constipation

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MariTide uses antibodies, and your body might produce anti-drug antibodies in response

Why rebound happens Metabolic adaptation Long-term weight maintenance is difficult partly because energy expenditure often drops more than expected after weight loss, a phenomenon known as adaptive thermogenesis, and that reduced expenditure can persist while weight is suppressed

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(2015) study