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Adopting a fresh perspective, targeting specific inhibitor pathways to stimulate ferroptosis represents a promising strategy to enhance sorafenibs drug resistance effectively
Research is ongoing, and more human studies are needed
The FOXO4p53 axis in senescence p53 is a major tumour suppressor and master regulator of cellular stress responses: DNA damage, oxidative stress, oncogene activation
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In summary, although the two neurons did not die of GPX4 reduction, the study focused on only one point of GPX4 and did not delve into other regulators, indicating that there are other pathways affecting the activity of POMC neurons under obesity conditions (129)
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