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Safety, risks & side effects GLP-1 medications carry real risks

There is decreased gastric acid that some nutrients require to be absorbed

SURMOUNT-5 was a phase 3b, open-label, controlled trial in 751 adults with obesity but without type 2 diabetes, randomized 1:1 to the maximum tolerated dose of tirzepatide (10 mg or 15 mg) or the maximum tolerated dose of semaglutide (1.7 mg or 2.4 mg), once weekly for 72 weeks

Erta M, Quintana A, Hidalgo J

2002) reflects how strongly they are associated with a direction

Elevated dopamine feels good, but you can have too much of a good thing and become desensitized to it, gradually requiring higher doses, more frequently, to achieve the same effect