by 2020, the top drug, Humira, more than doubled that revenue to ~$16 billion, but the number of patients treated collapsed to ~300,000
Bacterial-derived butyrate promotes the differentiation of colonic regulatory T cells, suppresses inappropriate mucosal immunity, and improves local colitis and distant arthritis (65, 66)
Furthermore, the increasing share of Medicare spending coming from general revenues and beneficiary premiums raises concerns about intergenerational equity and affordability
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