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Agonist-induced internalisation of the glucagon-like peptide-1 receptor is mediated by the Gq pathway

Firstly, there is a variation in tissue specificity

doi: 10.1038/s41580-024-00703-5 52 WenPSunZGouFWangJFanQZhaoDet al

Furthermore, GLP-1 receptor agonists improve CV risk factors, including body weight reduction, and lowered systolic blood pressure and LDL cholesterol

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As a result, semaglutide may support gradual weight loss when combined with dietary changes and regular activity