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Wu S, Gao L, Cipriani A, et al

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Their mechanisms diverge on several key fronts: GHK-Cu has documented antioxidant effects and MMP/TIMP modulatory activity, while retinoids primarily drive epidermal turnover and reduce UV-induced MMP activation

44 potential PROMs were identified and taken forward to Stage 2

Alongside pharmacological findings, our data indicate that ferroptosis defects caused by GPX4 overexpression significantly prevent the progression of fibrosis by blocking the expression of cytokines

However, mathematical modeling suggests that MCT inhibition alone may not significantly decrease lactate production due to autoregulatory feedback on flux control [213]