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Remarkably, the simple parsimonious model of a negative feedback in the GPCR signaling pathway captures the key features that we observed experimentally (Fig 2): An on step of the diacetyl stimulus resulted in a single calcium pulse, which decayed to baseline levels even though the stimulus remained constantly present (Fig 2A)
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Vitamin C works synergistically with glutathione and is generally well-tolerated by most skin types, with consistent use showing gradual improvements
