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Multiple highly effective anti-obesity medications are expensive, and insurers are opting out of coverage of these medications, leading to patients having to stop treatment [63] abruptly

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In adults with obesity or overweight and knee osteoarthritis, retatrutide at 12 mg produced 23.7% body weight loss (an average of 60 pounds) compared to 4.6% with placebo over a full treatment period

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Positive outcomes could expand their use