No significant heterogeneity was found among RCTs in the diabetic subgroup (I 2 = 0%, P = 0.38), and thus fix-effects model was chosen
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Utilizing a variety of animal models of TMJ OA caused by unilateral anterior crossbite (UAC), occlusion disorder (OD), monosodium iodoacetate (MIA), and IL-1, the study shows that ferroptosis, which is typified by elevated p53 and ACSL4 and decreased GPX4, is a major contributor to TMJ OA
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GLP-1 medications, such as Ozempic, Trulicity, and Wegovy, are designed to replicate these natural actions of GLP-1
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