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does semaglutide stop working GLP-1 drugs work while you're on them. The problem is what happens when you stop. Clinical trials show two-thirds of people regain the weight within a year of stopping — and Semaglutide Plateau: Why It Stops

Name: does semaglutide stop working GLP-1 drugs work while you're on them. The problem is what happens when you stop. Clinical trials show two-thirds of people regain the weight within a year of stopping — and Semaglutide Plateau: Why It Stops
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Intracellular amyloid-beta in Alzheimers disease

Our 2026 deep dive on how GLP-1 works explains the science behind those differences in more detail

In a 2022 study of tirzepatide participants who took a weekly 15 mg dose lost an average of 20.9% of their body weight over 72 weeks, compared with 3.1% in the placebo group