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No one should be taking these medicines without the guidance of a physician or other good providers, says Spencer Nadolsky, DO, the physician-founder of Vineyard.com, which abides by FDA criteria for prescribing GLP-1s, and offers access to registered dietitians and a strength coach

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A notable example is the CUR-PPR interaction: while PPR enhances CURs bioavailability by inhibiting CYP3A4 and P-gpcritical enzymes for CUR metabolismvia competitive binding to their active sites, this inhibition prolongs systemic CUR exposure

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doi: 10.1016/j.bbadis.2016.04.017 216 KullmannSKleinriddersASmallDMFritscheAHringHUPreisslHet al