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Altered social behaviours in neurexin 1 knockout mice resemble core symptoms in neurodevelopmental disorders
Amylin receptors (CALCR complexed with RAMPs 1, 2, or 3) are densely expressed in the area postrema and nucleus tractus solitarius of the brainstem, structures that have an incomplete blood-brain barrier and directly sense circulating peptides
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Table 2 [i] The adjusted mean differences and p-values were calculated using multiple linear regression analyses with adjustment for age, physical activity, alcohol intake, body mass index, estimated glomerular filtration rate, diabetes, hypertension, and dyslipidemia
A few concerning trends emerged
This is mechanistically distinct from proton pump inhibitor pharmacology and is part of why the peptide attracts interest as a research tool for ulcer biology and NSAID-induced gastric injury
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