maximus glp-1 GLP-1s: Your questions answered GLP-1 Microdosing: fat loss, metabolic

A new survey report from the International Foundation of Employee Benefit Plans reveals results from a group of Canadian employers regarding considerations and coverage for glucagon-like peptide-1 (GLP-1) drugs, which have historically been used to treat diabetes and are increasingly being used to treat obesity

Notable are the EMPA-REG OUTCOME trial, which showed a significant reduction in aminotransferases with empagliflozin 47 , and a meta-analysis of ten randomized controlled trials with 573 participants that confirmed the superiority of SGLT2 inhibitors over other antihyperglycemic agents in terms of improvement in hepatic and metabolic parameters 48

Additionally, LCLT may support testosterone levels and potentially offer cognitive benefits, though more research is needed in these areas

Abbreviations AE: Adverse event AgRP: Agouti-related peptide ALAT: Alanine aminotransferase Anti-CGRP mAbs: Monoclonal antibodies against calcitonin gene-related peptide AP: Area postrema BMI: Body mass index CART: Cocaine- and amphetamine-regulated transcript CGRP: Calcitonin gene-related peptide CSF: Cerebrospinal fluid ENS: Enteric nervous system FUP: Follow-up GCL: Ganglion cell layer GLP-1: Glucagon-like peptide-1 GLP-1-RA: Glucagon-like peptide-1 receptor agonist Hyp: Hypothalamus ICP: Intracranial pressure IIH: Idiopathic intracranial hypertension IIH-WOP: Idiopathic intracranial hypertension without papilledema MHD: Monthly headache days NPY: Neuropeptide Y NTS: Nucleus tractus solitarii OCT: Optical coherence tomography ONSD: Optic nerve sheath diameter POMS: Proopiomelanocortin pRNFL: Peripapillary retinal nerve fiber layer pwIIH: Patients with idiopathic intracranial hypertension SFO: Subfornical organ UCWM: Usual care weight management ULN: Upper limit of normal VIIH: Vienna Idiopathic Intracranial Hypertension References Mollan SP et al (2018) Idiopathic intracranial hypertension: consensus guidelines on management

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Tirzepatide produced even higher results in some studies