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In a short-term clinical trial, a shiitake-based mouth rinse significantly reduced dental plaque, gingival inflammation, and key oral pathogens, with effects comparable to a commercial antiseptic mouthwash

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Consult the conversion chart for dose equivalency guidance

As a small molecule, it does not require the reconstitution workflow associated with lyophilized peptides, and is reported soluble in water and in dimethyl sulfoxide (DMSO)

Always consult a healthcare professional before starting any new supplement.

Both modifications sit in the region that IGF binding proteins recognise, and the functional consequence is a large loss of IGFBP affinity while type 1 IGF receptor binding is largely preserved